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Patients with renal disease who undergo hemodialysis are at risk for secondary carnitine deficiency because hemodialysis removes carnitine from the blood (see End-stage renal disease) (38)

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The expression of GLS-2 is also positively regulated by wild-type TP53 , as such the conversion of glutamine-to-glutamate increases, which is requisite for supplement of NADPH and GSH (172, 173)